Targeted deletion of one or two copies of the G protein β subunit Gβ5 gene has distinct effects on body weight and behavior in mice

Abstract excerpt

ABSTRACT We investigated the physiological role of Gβ5, a unique G protein β subunit that dimerizes with regulators of G protein signaling (RGS) proteins of the R7 family instead of Gβ. Gβ5 is essential for stability of these complexes, so that its knockout (KO)causes degradation of the entire Gβ5‐R7 family. We report that the Gβ5‐KO mice remain leaner than the wild type (WT) throughout their lifetime and are...

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