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Article

Knockout of G protein β5 impairs brain development and causes multiple neurologic abnormalities in mice.

Journal of neurochemistry - 1 Nov 2011

Zhang Jian-Hua, Pandey Mritunjay, Seigneur Erica M, Panicker Leelamma M, Koo Lily, Schwartz Owen M, Chen Weiping, Chen Ching-Kang, Simonds William F

Abstract excerpt

Gβ5 is a divergent member of the signal-transducing G protein β subunit family encoded by GNB5 and expressed principally in brain and neuronal tissue. Among heterotrimeric Gβ isoforms, Gβ5 is unique in its ability to heterodimerize with members of the R7 subfamily of the regulator of G protein signaling proteins that contain G protein-γ like domains. Previous studies employing Gnb5 knockout (KO) mice have shown...

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Source

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Identifiers

PMID: 21883221
DOI: 10.1111/j.1471-4159.2011.07457.x
PMCID: PMC3192915

Genes

GNB5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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