Article
Resistance to diet-induced obesity in mice globally overexpressing OGH/GPB5.
Proceedings of the National Academy of Sciences of the United States of America - 15 Feb 2005
Macdonald Lynn E, Wortley Katherine E, Gowen Lori C, Anderson Keith D, Murray Jane D, Poueymirou William T, Simmons Mary V, Barber Dianna, Valenzuela David M, Economides Aris N, Wiegand Stanley J, Yancopoulos George D, Sleeman Mark W, Murphy Andrew J
Abstract excerpt
We identified a glycoprotein hormone beta-subunit (OGH, also called GPB5) that, as a heterodimer with the alpha-subunit GPA2, serves as a second ligand for the thyroid-stimulating hormone receptor. Mice in which the OGH gene is deleted (OGH-/-) are indistinguishable from WT littermates in body weight, response to high-fat diet, metabolic parameters, body composition, and insulin tolerance. Mice engineered to...
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