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Article

Loss of Cytokine-STAT5 Signaling in the CNS and Pituitary Gland Alters Energy Balance and Leads to Obesity

20 Feb 2008

Abstract excerpt

Signal transducers and activators of transcription (STATs) are critical components of cytokine signaling pathways. STAT5A and STAT5B (STAT5), the most promiscuous members of this family, are highly expressed in specific populations of hypothalamic neurons in regions known to mediate the actions of cytokines in the regulation of energy balance. To test the hypothesis that STAT5 signaling is essential to energy...

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Share to Adipokines, Inflammation, and Metabolic Diseases
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PMID: 18286195
DOI: 10.1371/journal.pone.0001639

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