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Article

Role of VGF-derived carboxy-terminal peptides in energy balance and reproduction: analysis of "humanized" knockin mice expressing full-length or truncated VGF.

Endocrinology - 1 May 2015

Sadahiro Masato, Erickson Connor, Lin Wei-Jye, Shin Andrew C, Razzoli Maria, Jiang Cheng, Fargali Samira, Gurney Allison, Kelley Kevin A, Buettner Christoph, Bartolomucci Alessandro, Salton Stephen R

Abstract excerpt

Targeted deletion of VGF, a secreted neuronal and endocrine peptide precursor, produces lean, hypermetabolic, and infertile mice that are resistant to diet-, lesion-, and genetically-induced obesity and diabetes. Previous studies suggest that VGF controls energy expenditure (EE), fat storage, and...

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Source

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Identifiers

PMID: 25675362
DOI: 10.1210/en.2014-1826
PMCID: PMC4398760

Genes

VGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25675362-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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