Article
Gsα deficiency in the paraventricular nucleus of the hypothalamus partially contributes to obesity associated with Gsα mutations.
Endocrinology - 1 Sept 2012
Chen Min, Berger Alta, Kablan Ahmed, Zhang Jiandi, Gavrilova Oksana, Weinstein Lee S
Abstract excerpt
The G protein α-subunit G(s)α mediates receptor-stimulated cAMP generation. Heterozygous inactivating G(s)α mutations on the maternal allele result in obesity primarily due to reduced energy expenditure in Albright hereditary osteodystrophy patients and in mice. We previously showed that mice with central nervous system (CNS)-specific G(s)α deletion on the maternal allele (mBrGs KO) also develop severe obesity...
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