Article
The metalloprotease of Listeria monocytogenes is regulated by pH.
Journal of bacteriology - 1 Oct 2011
Forster Brian M, Bitar Alan Pavinski, Slepkov Emily R, Kota Karthik J, Sondermann Holger, Marquis Hélène
Abstract excerpt
Listeria monocytogenes is an intracytosolic bacterial pathogen. Among the factors contributing to escape from vacuoles are a phosphatidylcholine phospholipase C (PC-PLC) and a metalloprotease (Mpl). Both enzymes are translocated across the bacterial membrane as inactive proproteins, whose propeptides serve in part to maintain them in association with the bacterium. We have shown that PC-PLC maturation is...
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