Article
Plasticity of listeriolysin O pores and its regulation by pH and unique histidine [corrected].
Scientific reports - 8 Apr 2015
Podobnik Marjetka, Marchioretto Marta, Zanetti Manuela, Bavdek Andrej, Kisovec Matic, Cajnko Miša Mojca, Lunelli Lorenzo, Dalla Serra Mauro, Anderluh Gregor
Abstract excerpt
Pore formation of cellular membranes is an ancient mechanism of bacterial pathogenesis that allows efficient damaging of target cells. Several mechanisms have been described, however, relatively little is known about the assembly and properties of pores. Listeriolysin O (LLO) is a pH-regulated cholesterol-dependent cytolysin from the intracellular pathogen Listeria monocytogenes, which forms transmembrane...
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