Article
Phospholipases C and the pathogenesis of Listeria.
Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas - 1 Feb 1994
Portnoy D A, Smith G A, Goldfine H
Abstract excerpt
Listeria monocytogenes is a model intracellular pathogen which escapes from a host cell vacuole, grows intracytoplasmically, and spreads cell to cell without an extracellular phase. A number of genes necessary for pathogenicity have been discovered, two of which encode phospholipases C, a PI-PLC and a broad-range PLC. Single and double mutants were constructed with in-frame deletions in one or both PLCs....
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