Article
Characterization of Listeria monocytogenes expressing anthrolysin O and phosphatidylinositol-specific phospholipase C from Bacillus anthracis.
Infection and immunity - 1 Oct 2005
Wei Zhengyu, Schnupf Pamela, Poussin Mathilde A, Zenewicz Lauren A, Shen Hao, Goldfine Howard
Abstract excerpt
Two virulence factors of Listeria monocytogenes, listeriolysin O (LLO) and phosphatidylinositol-specific phospholipase C (PI-PLC), mediate escape of this pathogen from the phagocytic vacuole of macrophages, thereby allowing the bacterium access to the host cell cytosol for growth and spread to neighboring cells. We characterized their orthologs from Bacillus anthracis by expressing them in L. monocytogenes and...
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