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Article

Listeriolysin O: a genuine cytolysin optimized for an intracellular parasite.

The Journal of cell biology - 18 Mar 2002

Dramsi Shaynoor, Cossart Pascale

Abstract excerpt

Cholesterol-dependent cytolysins (CDCs)* are produced by a large number of pathogenic gram-positive bacteria. A member of this family, listeriolysin O (LLO), is produced by the intracellular pathogen Listeria monocytogenes. A unique feature of LLO is its low optimal pH activity (approximately 6) which permits escape of the bacterium from the phagosome into the host cell cytosol without damaging the plasma...

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Identifiers

PMID: 11901162
DOI: 10.1083/jcb.200202121
PMCID: PMC2173465

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Listeriolysin O: a genuine cytolysin optimized for an intracellular parasite.PMID 11901162Read ↗

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Plasticity of listeriolysin O pores and its regulation by pH and unique histidine [corrected].Semantic proximity Read ↗

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Phosphorylation, ubiquitination and degradation of listeriolysin O in mammalian cells: role of the PEST-like sequence.Semantic proximity Read ↗

Association of listeriolysin O with the cell surface of Listeria monocytogenes.Semantic proximity Read ↗

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pH-dependent perforation of macrophage phagosomes by listeriolysin O from Listeria monocytogenes.Semantic proximity Read ↗

Development of a single-gene, signature-tag-based approach in combination with alanine mutagenesis to identify listeriolysin O residues critical for the in vivo survival of Listeria monocytogenes.Semantic proximity Read ↗

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