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Article

A PEST-like sequence in listeriolysin O essential for Listeria monocytogenes pathogenicity.

Science (New York, N.Y.) - 3 Nov 2000

Decatur A L, Portnoy D A

Abstract excerpt

Establishment and maintenance of an intracellular niche are critical to the success of an intracellular pathogen. Here, the pore-forming protein listeriolysin O (LLO), secreted by Listeria monocytogenes, was shown to contain a PEST-like sequence (P, Pro; E, Glu; S, Ser; T, Thr) that is essential for the virulence and intracellular compartmentalization of this pathogen. Mutants lacking the PEST-like sequence...

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Identifiers

PMID: 11062133
DOI: 10.1126/science.290.5493.992

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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A PEST-like sequence in listeriolysin O essential for Listeria monocytogenes pathogenicity.PMID 11062133Read ↗

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The Listeria monocytogenes hemolysin has an acidic pH optimum to compartmentalize activity and prevent damage to infected host cells.Semantic proximity Read ↗

Listeriolysin O: a genuine cytolysin optimized for an intracellular parasite.Semantic proximity Read ↗

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Mutants of listeriolysin O for enhanced liposomal delivery of macromolecules.Semantic proximity Read ↗

Modification of the signal sequence cleavage site of listeriolysin O does not affect protein secretion but impairs the virulence of Listeria monocytogenes.Semantic proximity Read ↗

Development of a mariner-based transposon and identification of Listeria monocytogenes determinants, including the peptidyl-prolyl isomerase PrsA2, that contribute to its hemolytic phenotype.Semantic proximity Read ↗

Regulated translation of listeriolysin O controls virulence of Listeria monocytogenes.Semantic proximity Read ↗

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Protective immunity induced by a LLO-deficient Listeria monocytogenes.Semantic proximity Read ↗

Development of a single-gene, signature-tag-based approach in combination with alanine mutagenesis to identify listeriolysin O residues critical for the in vivo survival of Listeria monocytogenes.Semantic proximity Read ↗

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