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Article

pH sensing by intracellular Salmonella induces effector translocation.

Science (New York, N.Y.) - 21 May 2010

Yu Xiu-Jun, McGourty Kieran, Liu Mei, Unsworth Kate E, Holden David W

Abstract excerpt

Salmonella enterica is an important intracellular bacterial pathogen of humans and animals. It replicates within host-cell vacuoles by delivering virulence (effector) proteins through a vacuolar membrane pore made by the Salmonella pathogenicity island 2 (SPI-2) type III secretion system (T3SS). T3SS assembly follows vacuole acidification, but when bacteria are grown at low pH, effector secretion is negligible....

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Identifiers

PMID: 20395475
DOI: 10.1126/science.1189000
PMCID: PMC6485629

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