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Article

Cerebrospinal fluid cortisol concentrations in healthy elderly are affected by both APOE and TOMM40 variants.

Psychoneuroendocrinology - 1 Mar 2012

Bruno Davide, Nierenberg Jay J, Ritchie James C, Lutz Michael W, Pomara Nunzio

Abstract excerpt

Abnormalities of the hypothalamic-pituitary-adrenal (HPA) axis have been reported in subjects with Alzheimer's disease (AD) and may include increased cerebrospinal fluid (CSF) cortisol concentrations. Moreover, presence of the APOE ɛ4 allele, which is an established risk factor for the development of AD, has been shown to associate with higher CSF cortisol levels, especially in AD sufferers. In this study, we...

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Identifiers

PMID: 21803501
DOI: 10.1016/j.psyneuen.2011.07.006
PMCID: PMC3207029

Genes

APOE
TOMM40

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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