Article

Early Alzheimer’s brain atrophy in entorhinal cortex is associated with HSD11B1-cortisol axis in APOE4 carriers

2025-02-18

Abstract excerpt

<title>Abstract</title> <p>Background Entorhinal cortex (EC) atrophy, driven by tau pathology, is an early hallmark of Alzheimer’s disease (AD), preceding hippocampal degeneration. <italic>APOE4</italic>, the strongest genetic risk factor for AD, is linked to increased tau accumulation and impaired Aβ clearance in the EC. However, the specific cellular factors associated with <italic>APOE4</italic> that contribu...

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Literature Corpus work: 889aeac4-60ae-5786-8541-a508447fc906
DOI: 10.21203/rs.3.rs-6011135/v1

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