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Article

Stress hormone leads to memory deficits and altered tau phosphorylation in a model of Alzheimer's disease.

Journal of Alzheimer's disease : JAD - 1 Jan 2012

Joshi Yash B, Chu Jin, Praticò Domenico

Abstract excerpt

Several studies have linked stress with Alzheimer's disease (AD) vulnerability; however, the mechanism remains to be fully elucidated. In the current paper, we investigated the role of glucocortitcoids on the AD-like phenotype. We administered the glucocorticoid dexamethasone to Tg2576 mice for 4 weeks and then investigated its effect on memory, amyloid-β and tau levels, and metabolism. At the end of the...

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Identifiers

PMID: 22531419
DOI: 10.3233/JAD-2012-120328
PMCID: PMC3882896

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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