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Article

Increased CSF cortisol in AD is a function of APOE genotype.

Neurology - 24 Apr 2001

Peskind E R, Wilkinson C W, Petrie E C, Schellenberg G D, Raskind M A

Abstract excerpt

BACKGROUND: Increased hypothalamic-pituitary-adrenal (HPA) axis activity manifested by elevated cortisol levels is observed in AD and may contribute to AD by lowering the threshold for neuronal degeneration. Presence of the APOE-epsilon4 allele increases risk for AD. Increased cortisol concentrat...

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Source

Identifiers

PMID: 11320185
DOI: 10.1212/wnl.56.8.1094

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026. Prepared record publication-11320185-2026-08-31.1. Manifest publication-graph-cohort-2026-08-31.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 31 Aug 2026.

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