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Article

A re-evaluation of two key reagents for in vivo studies of Wnt signaling.

Developmental dynamics : an official publication of the American Association of Anatomists - 1 Sept 2011

Ahrens Molly J, Romereim Sarah, Dudley Andrew T

Abstract excerpt

Conditional mutations and transcription-based reporters are important new tools for exploring the dynamic functions of biological pathways in vivo. While studying the role of the Wnt signaling pathway in cartilage, we observed that the β-catenin-dependent reporter TOPGAL was expressed in chondrocytes in which β-catenin was conditionally inactivated using a Col2a1::cre driver. Here we show that in these embryos...

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Identifiers

PMID: 21793100
DOI: 10.1002/dvdy.22704
PMCID: PMC3192924

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