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Article

A new gain-of-function mouse line to study the role of Wnt3a in development and disease.

Genesis (New York, N.Y. : 2000) - 1 Sept 2016

Chalamalasetty Ravindra B, Ajima Rieko, Garriock Robert J, Kennedy Mark W, Tessarollo Lino, Yamaguchi Terry P

Abstract excerpt

Wnt/β-catenin signals are important regulators of embryonic and adult stem cell self-renewal and differentiation and play causative roles in tumorigenesis. Purified recombinant Wnt3a protein, or Wnt3a-conditioned culture medium, has been widely used to study canonical Wnt signaling in vitro or ex vivo. To study the role of Wnt3a in embryogenesis and cancer models, we developed a Cre recombinase activatable...

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Identifiers

PMID: 27411055
DOI: 10.1002/dvg.22959
PMCID: PMC6667172

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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