Article
Generation of an allele to inactivate Wnt4 gene function conditionally in the mouse.
Genesis (New York, N.Y. : 2000) - 1 Nov 2009
Shan Jingdong, Jokela Tiina, Peltoketo Hellevi, Vainio Seppo
Abstract excerpt
The Wnt family member Wnt4 is critical for the development of several organs, including the kidney, gonad, and adrenal, mammary, and pituitary glands. To study its potential postnatal functions, we generated a floxed Wnt4 allele. A single loxP site was targeted to the second intron, while a loxP-Neo-loxP cassette was placed 3' from Exon 5. The floxed Neo cassette was subsequently removed by crossing with MeuCre40...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.