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Article

Knockout mouse models to study Wnt signal transduction.

Trends in genetics : TIG - 1 Dec 2006

van Amerongen Renée, Berns Anton

Abstract excerpt

Wnt signal transduction is crucial for maintaining the balance between proliferation and differentiation throughout embryogenesis and postnatal life. Here, we provide a comprehensive overview of the conventional knockout mouse studies of both the canonical and the noncanonical Wnt pathways during mammalian development. Many of these knockout mice display early embryonic lethality, underscoring the fundamental...

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PMID: 17045694
DOI: 10.1016/j.tig.2006.10.001

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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