Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Effects of genetic variants in ADCY5, GIPR, GCKR and VPS13C on early impairment of glucose and insulin metabolism in children.

PloS one - 1 Jan 2011

Windholz Jan, Kovacs Peter, Tönjes Anke, Dittrich Kathrin, Blüher Susann, Kiess Wieland, Stumvoll Michael, Körner Antje

Abstract excerpt

OBJECTIVE: Recent genome-wide association studies identified novel candidate genes for fasting and 2 h blood glucose and insulin levels in adults. We investigated the role of four of these loci (ADCY5, GIPR, GCKR and VPS13C) in early impairment of glucose and insulin metabolism in children. RESEARCH DESIGN AND METHODS: We genotyped four variants (rs2877716; rs1260326; rs10423928; rs17271305) in 638 Caucasian...

Read the complete abstract on PubMed

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adaptor Proteins, Signal Transducing
Share to Adenylyl Cyclases
Share to Demography
Share to Genome-Wide Association Study
Share to Glucose
Share to Insulin
Share to Obesity
Share to Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 21789219
DOI: 10.1371/journal.pone.0022101
PMCID: PMC3137620

Genes

ADCY5
GCKR
GIPR
SDS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Effects of genetic variants in ADCY5, GIPR, GCKR and VPS13C on early impairment of glucose and insulin metabolism in children.PMID 21789219Read ↗

Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge.Semantic proximity Read ↗

Association of genetic Loci with glucose levels in childhood and adolescence: a meta-analysis of over 6,000 children.Semantic proximity Read ↗

Genetic Susceptibility Determines β-Cell Function and Fasting Glycemia Trajectories Throughout Childhood: A 12-Year Cohort Study (EarlyBird 76).Semantic proximity Read ↗

Glucose-raising genetic variants in MADD and ADCY5 impair conversion of proinsulin to insulin.Semantic proximity Read ↗

Variants at DGKB/TMEM195, ADRA2A, GLIS3 and C2CD4B loci are associated with reduced glucose-stimulated beta cell function in middle-aged Danish people.Semantic proximity Read ↗

A Genome-Wide Association Study of IVGTT-Based Measures of First-Phase Insulin Secretion Refines the Underlying Physiology of Type 2 Diabetes Variants.Semantic proximity Read ↗

Genetic determinants of circulating GIP and GLP-1 concentrations.Semantic proximity Read ↗

Secretory granule neuroendocrine protein 1 (SGNE1) genetic variation and glucose intolerance in severe childhood and adult obesity.Semantic proximity Read ↗

Detailed physiologic characterization reveals diverse mechanisms for novel genetic Loci regulating glucose and insulin metabolism in humans.Semantic proximity Read ↗

Risk Alleles in/near ADCY5, ADRA2A, CDKAL1, CDKN2A/B, GRB10, and TCF7L2 Elevate Plasma Glucose Levels at Birth and in Early Childhood: Results from the FAMILY Study.Semantic proximity Read ↗

A common variant upstream of the PAX6 gene influences islet function in man.Semantic proximity Read ↗

Genetic evidence that high BMI in childhood has a protective effect on intermediate diabetes traits, including measures of insulin sensitivity and secretion, after accounting for BMI in adulthood.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.