Article
Genetic evidence that high BMI in childhood has a protective effect on intermediate diabetes traits, including measures of insulin sensitivity and secretion, after accounting for BMI in adulthood.
Diabetologia - 1 Aug 2023
Hawkes Gareth, Beaumont Robin N, Tyrrell Jessica, Power Grace M, Wood Andrew, Laakso Markku, Fernandes Silva Lilian, Boehnke Michael, Yin Xianyong, Richardson Tom G, Smith George Davey, Frayling Timothy M
Abstract excerpt
AIMS/HYPOTHESIS: Determining how high BMI at different time points influences the risk of developing type 2 diabetes and affects insulin secretion and insulin sensitivity is critical. METHODS: By estimating childhood BMI in 441,761 individuals in the UK Biobank, we identified which genetic variants had larger effects on adulthood BMI than on childhood BMI, and vice versa. All genome-wide significant genetic...
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