Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetic determinants of circulating GIP and GLP-1 concentrations.

JCI insight - 2 Nov 2017

Almgren Peter, Lindqvist Andreas, Krus Ulrika, Hakaste Liisa, Ottosson-Laakso Emilia, Asplund Olof, Sonestedt Emily, Prasad Rashmi B, Laurila Esa, Orho-Melander Marju, Melander Olle, Tuomi Tiinamaija, Holst Jens Juul, Nilsson Peter M, Wierup Nils, Groop Leif, Ahlqvist Emma

Abstract excerpt

The secretion of insulin and glucagon from the pancreas and the incretin hormones glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic peptide (GIP) from the gastrointestinal tract is essential for glucose homeostasis. Several novel treatment strategies for type 2 diabetes (T2D) mimic GLP-1 actions or inhibit incretin degradation (DPP4 inhibitors), but none is thus far aimed at increasing the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to ABO Blood-Group System
Share to Dipeptidyl Peptidase 4

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gastrointestinal Tract

Share to Glucagon

Share to Glucagon-Like Peptide 1

Share to Glucose Tolerance Test

Share to Insulin-Secreting Cells

Share to Islets of Langerhans

Source

Open in PubMed Open full text

Identifiers

PMID: 29093273
DOI: 10.1172/jci.insight.93306
PMCID: PMC5963138

Genes

GIP
ABO
GIPR
HOXD1
DPP4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic determinants of circulating GIP and GLP-1 concentrations.PMID 29093273Read ↗

Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge.Semantic proximity Read ↗

Genetically proxied impaired GIPR signaling and risk of 6 cancersSemantic proximity Read ↗

Low-frequency and rare exome chip variants associate with fasting glucose and type 2 diabetes susceptibility.Semantic proximity Read ↗

Variants from GIPR, TCF7L2, DGKB, MADD, CRY2, GLIS3, PROX1, SLC30A8 and IGF1 are associated with glucose metabolism in the Chinese.Semantic proximity Read ↗

Global genomic and transcriptomic analysis of human pancreatic islets reveals novel genes influencing glucose metabolismSemantic proximity Read ↗

Identification and functional characterization of G6PC2 coding variants influencing glycemic traits define an effector transcript at the G6PC2-ABCB11 locus.Semantic proximity Read ↗

Genome-wide cross-disease analyses highlight causality and shared biological pathways of type 2 diabetes with gastrointestinal disordersSemantic proximity Read ↗

Effects of common genetic variants associated with type 2 diabetes and glycemic traits on α- and β-cell function and insulin action in humans.Semantic proximity Read ↗

Common variants of GIP are associated with visceral fat accumulation in Japanese adults.Semantic proximity Read ↗

Human pancreatic islet microRNAs implicated in diabetes and related traits by large-scale genetic analysisSemantic proximity Read ↗

Detailed physiologic characterization reveals diverse mechanisms for novel genetic Loci regulating glucose and insulin metabolism in humans.Semantic proximity Read ↗

Genome-wide cross-disease analyses highlight causality and shared biological pathways of type 2 diabetes with gastrointestinal disorders.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.