Article
Risk Alleles in/near ADCY5, ADRA2A, CDKAL1, CDKN2A/B, GRB10, and TCF7L2 Elevate Plasma Glucose Levels at Birth and in Early Childhood: Results from the FAMILY Study.
PloS one - 1 Jan 2016
Sohani Zahra N, Anand Sonia S, Robiou-du-Pont Sebastien, Morrison Katherine M, McDonald Sarah D, Atkinson Stephanie A, Teo Koon K, Meyre David
Abstract excerpt
BACKGROUND: Metabolic abnormalities that lead to type 2 diabetes mellitus begin in early childhood. OBJECTIVES: We investigate whether common genetic variants identified in adults have an effect on glucose in early life. METHODS: 610 newborns, 463 mothers, and 366 fathers were included in the present study. Plasma glucose and anthropometric characteristics were collected at birth, 3, and 5 years. After quality...
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