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Article

Glucose-raising genetic variants in MADD and ADCY5 impair conversion of proinsulin to insulin.

PloS one - 1 Jan 2011

Wagner Robert, Dudziak Katarzyna, Herzberg-Schäfer Silke A, Machicao Fausto, Stefan Norbert, Staiger Harald, Häring Hans-Ulrich, Fritsche Andreas

Abstract excerpt

INTRODUCTION: Recent meta-analyses of genome-wide association studies revealed new genetic loci associated with fasting glycemia. For several of these loci, the mechanism of action in glucose homeostasis is unclear. The objective of the study was to establish metabolic phenotypes for these genetic variants to deliver clues to their pathomechanism. METHODS: In this cross-sectional study 1782 non-diabetic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 21887289
DOI: 10.1371/journal.pone.0023639
PMCID: PMC3161735

Genes

MADD
ADCY5
PROX1
DGKB
GLIS3
CRY2
FADS1
GCK
GCKR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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Glucose-raising genetic variants in MADD and ADCY5 impair conversion of proinsulin to insulin.PMID 21887289Read ↗

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