Article
Genetic Susceptibility Determines β-Cell Function and Fasting Glycemia Trajectories Throughout Childhood: A 12-Year Cohort Study (EarlyBird 76).
Diabetes care - 1 Mar 2020
Carayol Jerome, Hosking Joanne, Pinkney Jonathan, Marquis Julien, Charpagne Aline, Metairon Sylviane, Jeffery Alison, Hager Jörg, Martin Francois-Pierre
Abstract excerpt
OBJECTIVE: Previous studies suggested that childhood prediabetes may develop prior to obesity and be associated with relative insulin deficiency. We proposed that the insulin-deficient phenotype is genetically determined and tested this hypothesis by longitudinal modeling of insulin and glucose traits with diabetes risk genotypes in the EarlyBird cohort. RESEARCH DESIGN AND METHODS: EarlyBird is a nonintervention...
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