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Article

Variants at DGKB/TMEM195, ADRA2A, GLIS3 and C2CD4B loci are associated with reduced glucose-stimulated beta cell function in middle-aged Danish people.

Diabetologia - 1 Aug 2010

Boesgaard T W, Grarup N, Jørgensen T, Borch-Johnsen K, Hansen T, Pedersen O

Abstract excerpt

AIMS/HYPOTHESIS: A meta-analysis of 21 genome-wide association studies identified 11 novel genetic loci implicated in fasting glucose homeostasis. We aimed to evaluate the impact of these variants on insulin release and insulin sensitivity estimated from OGTTs. METHODS: Eleven variants in or near DGKB/TMEM195, ADCY5, MADD, ADRA2A, FADS1, CRY2, SLC2A2, GLIS3, PROX1, C2CD4B and IGF1 were genotyped in 6,784...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 20419449
DOI: 10.1007/s00125-010-1753-5

Genes

DGKB
GLIS3
CRY2
FADS1
PROX1
ADCY5
IGF1
MADD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Variants at DGKB/TMEM195, ADRA2A, GLIS3 and C2CD4B loci are associated with reduced glucose-stimulated beta cell function in middle-aged Danish people.PMID 20419449Read ↗

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New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk.Semantic proximity Read ↗

Variants from GIPR, TCF7L2, DGKB, MADD, CRY2, GLIS3, PROX1, SLC30A8 and IGF1 are associated with glucose metabolism in the Chinese.Semantic proximity Read ↗

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