Article
Mutant lac repressors with new specificities hint at rules for protein--DNA recognition.
The EMBO journal - 1 Mar 1990
Lehming N, Sartorius J, Kisters-Woike B, von Wilcken-Bergmann B, Müller-Hill B
Abstract excerpt
Proteins which recognize specific sequences of DNA play a fundamental role in the regulation of protein synthesis in all organisms. A particular helix of the bacterial protein lac repressor recognizes the bases in the major groove of the lac operator. We show that the first two residues of this r...
Topics
- Amino Acid Sequence
- Base Sequence
- Escherichia coli
- Lac Operon
- Molecular Sequence Data
- Mutation
- Protein Conformation
- Repressor Proteins
- Transcription Factors