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Article

Mutant lac repressors with new specificities hint at rules for protein--DNA recognition.

The EMBO journal - 1 Mar 1990

Lehming N, Sartorius J, Kisters-Woike B, von Wilcken-Bergmann B, Müller-Hill B

Abstract excerpt

Proteins which recognize specific sequences of DNA play a fundamental role in the regulation of protein synthesis in all organisms. A particular helix of the bacterial protein lac repressor recognizes the bases in the major groove of the lac operator. We show that the first two residues of this recognition helix interact independently with two base pairs. This allows us in many cases to predict repression as an...

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Identifiers

PMID: 2178920
DOI: 10.1002/j.1460-2075.1990.tb08153.x
PMCID: PMC551714

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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