Article
Lac repressor genetic map in real space.
Trends in biochemical sciences - 1 Sept 1997
Pace H C, Kercher M A, Lu P, Markiewicz P, Miller J H, Chang G, Lewis M
Abstract excerpt
Here, we present a graphic display of the phenotypes of more than 4000 single amino acid substitution mutations on the three-dimensional structure of the lac repressor tetramer bound to DNA. The genetic data and the X-ray diffraction studies contribute to define an allosteric mechanism and yield a visual demonstration of the importance of core or buried residues in protein structure.
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