Article
Lac repressor genetic map in real space.
Trends in biochemical sciences - 1 Sept 1997
Pace H C, Kercher M A, Lu P, Markiewicz P, Miller J H, Chang G, Lewis M
Abstract excerpt
Here, we present a graphic display of the phenotypes of more than 4000 single amino acid substitution mutations on the three-dimensional structure of the lac repressor tetramer bound to DNA. The genetic data and the X-ray diffraction studies contribute to define an allosteric mechanism and yield...
Topics
- Allosteric Site
- Bacterial Proteins
- Escherichia coli
- Escherichia coli Proteins
- Lac Repressors
- Models, Molecular
- Mutation
- Protein Conformation
- Repressor Proteins