DNA-binding properties of a lac repressor mutant incapable of forming tetramers.

Article

DNA-binding properties of a lac repressor mutant incapable of forming tetramers.

The Journal of biological chemistry - 15 Jan 1991

Brenowitz M, Mandal N, Pickar A, Jamison E, Adhya S

Abstract excerpt

The interaction of proteins bound to sites widely separated on the genome is a recurrent motif in both prokaryotic and eukaryotic regulatory systems. Lac repressor mediates the formation of "DNA loops" by the simultaneous interaction of a single protein tetramer with two DNA-binding sites. The DN...

Topics

Autoradiography
Binding Sites
Chromatography, Gel
DNA, Bacterial
Mutation
Plasmids
Repressor Proteins

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