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Article

Mutant lambda repressors with increased operator affinities reveal new, specific protein-DNA contacts.

Genetics - 1 Jan 1992

Benson N, Adams C, Youderian P

Abstract excerpt

The binding specificities of four mutant lambda cI repressor proteins with increased affinities for operator DNA were examined. Two mutant repressors (Glu34----Lys and Glu83----Lys) have the same specificity of binding as wild-type repressor, whereas two (Gly48----Ser and Gly48----Asn) have new binding specificities. The Gly48----Asn mutant repressor recognizes lambda operators with changes at base pair 3 with a...

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Identifiers

PMID: 1531047
DOI: 10.1093/genetics/130.1.17
PMCID: PMC1204790

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