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Article

Rat Ace allele variation determines susceptibility to AngII-induced renal damage.

Journal of the renin-angiotensin-aldosterone system : JRAAS - 1 Dec 2011

Kamilic Jelena, Hamming Inge, Lely A Titia, Korstanje Ron, Schulze Ute, Poppinga Wilfred J, Turner Anthony J, Clarke Nicola E, van Goor Harry, Navis Gerjan J

Abstract excerpt

INTRODUCTION: Ace b/l polymorphism in rats is associated with differential tissue angiotensin-converting enzyme (ACE) expression and activity, and susceptibility to renal damage. Same polymorphism was recently found in outbred Wistar rat strain with b allele accounting for higher renal ACE, and provided a model for studying renin-angiotensin-aldosterone system (RAAS) response behind the innate high or low ACE...

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Identifiers

PMID: 21788250
DOI: 10.1177/1470320311415886
PMCID: PMC3356861

Genes

ACE
ACE2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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