Article
Angiotensin I-converting enzyme genotype influences arterial response to injury in normotensive rats.
Arteriosclerosis, thrombosis, and vascular biology - 1 Feb 1998
Challah M, Villard E, Philippe M, Ribadeau-Dumas A, Giraudeau B, Janiak P, Vilaine J P, Soubrier F, Michel J B
Abstract excerpt
Two normotensive strains of rat, the Lou and Brown Norway (BN) strains, have contrasting levels of plasma angiotensin-converting enzyme (ACE). To investigate the degree of genetic determination of ACE expression, a polymorphic marker of the ACE gene was analyzed in inbred rats of the two strains. The two inbred strains were shown to bear different alleles for a polymorphic marker at the ACE gene. The segregation...
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