Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Regulation of hepatic stem/progenitor phenotype by microenvironment stiffness in hydrogel models of the human liver stem cell niche.

Biomaterials - 1 Oct 2011

Lozoya Oswaldo A, Wauthier Eliane, Turner Rachael A, Barbier Claire, Prestwich Glenn D, Guilak Farshid, Superfine Richard, Lubkin Sharon R, Reid Lola M

Abstract excerpt

Human livers have maturational lineages of cells within liver acini, beginning periportally in stem cell niches, the canals of Hering, and ending in polyploid hepatocytes pericentrally and cholangiocytes in bile ducts. Hepatic stem cells (hHpSCs) in vivo are partnered with mesenchymal precursors to endothelia (angioblasts) and stellate cells, and reside in regulated microenvironments, stem cell niches, containing...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Survival
Share to Diffusion

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Elasticity

Share to Hyaluronic Acid

Share to Hydrogels

Share to Stem Cell Niche

Share to Stem Cells

Source

Open in PubMed Open full text

Identifiers

PMID: 21788068
DOI: 10.1016/j.biomaterials.2011.06.042
PMCID: PMC3157321

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Regulation of hepatic stem/progenitor phenotype by microenvironment stiffness in hydrogel models of the human liver stem cell niche.PMID 21788068Read ↗

Inducing endoderm differentiation by modulating mechanical properties of soft substrates.Semantic proximity Read ↗

Heterogeneous matrix stiffness regulates the cancer stem-like cell phenotype in hepatocellular carcinoma.Semantic proximity Read ↗

Mechano-modulatory synthetic niches for liver organoid derivationSemantic proximity Read ↗

Mechanical signalling through collagen I regulates cholangiocyte specification and tubulogenesis during liver developmentSemantic proximity Read ↗

Viscoelastic Notch Signaling Hydrogel Induces Liver Bile Duct Organoid Growth and MorphogenesisSemantic proximity Read ↗

Human hepatoblast phenotype maintained by hyaluronan hydrogels.Semantic proximity Read ↗

High throughput interrogation of human liver stellate cells reveals microenvironmental regulation of phenotype.Semantic proximity Read ↗

Cyclic mechanical stretching stimuli promotes angiocrine signals during <i>in vitro</i> liver bud formation from human pluripotent stem cellsSemantic proximity Read ↗

Advances in Extracellular Matrix-Mimetic Hydrogels to Guide Stem Cell FateSemantic proximity Read ↗

Perivascular Secretome Influences Hematopoietic Stem Cell Maintenance in a Gelatin HydrogelSemantic proximity Read ↗

Substrate stiffness induced mechanotransduction regulates temporal evolution of human fetal neural progenitor cell phenotype, differentiation, and biomechanics.Semantic proximity Read ↗

A cell-instructive hydrogel to regulate malignancy of 3D tumor spheroids with matrix rigidity.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.