Article
Human hepatoblast phenotype maintained by hyaluronan hydrogels.
Journal of biomedical materials research. Part B, Applied biomaterials - 1 Jul 2007
Turner William S, Schmelzer Eva, McClelland Randall, Wauthier Eliane, Chen Weiliam, Reid Lola M
Abstract excerpt
Human hepatoblasts and hepatic stem cells, pluripotent hepatic progenitors that give rise to hepatocytes and biliary cells, were isolated from fetal livers and found to express hyaluronan receptors (CD44) in both the freshly isolated cells and after culture. This implicates an in vivo connection to hyaluronan (HA), an embryonic matrix component, as a candidate 3-dimensional (3-D) scaffold for hepatic progenitor...
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