Article

Perivascular Secretome Influences Hematopoietic Stem Cell Maintenance in a Gelatin Hydrogel

2020-04-27

Abstract excerpt

<h4>ABSTRACT</h4> Adult hematopoietic stem cells (HSCs) produce the body’s full complement of blood and immune cells. They reside in specialized microenvironments, or niches, within the bone marrow. The perivascular niche near blood vessels is believed to help maintain primitive HSCs in an undifferentiated state but demonstration of this effect is difficult. In vivo studies make it challenging to determine the d...

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Literature Corpus work: fd94de06-d9b8-51ae-b6df-c83753e3085e
DOI: 10.1101/2020.04.25.061572

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