Article
Retrotransposons as mutagens in the induction of growth autonomy in hematopoietic cells.
Oncogene - 1 Dec 1990
Heberlein C, Kawai M, Franz M J, Beck-Engeser G, Daniel C P, Ostertag W, Stocking C
Abstract excerpt
Factor-independent mutants of hematopoietic cells, especially of multipotent cells, are valuable tools to identify genes that regulate stem cell proliferation and differentiation and thus may be important in leukemogenesis. Factor-independent mutants from both myeloid precursor and hematopoietic stem cell lines were isolated. The frequency of such mutants in a given cell population was one to two orders of...
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