Article
Expression of the GM-CSF gene after retroviral transfer in hematopoietic stem cell lines induces synchronous granulocyte-macrophage differentiation.
Cell - 22 Mar 1991
Just U, Stocking C, Spooncer E, Dexter T M, Ostertag W
Abstract excerpt
Multipotent murine stem cell lines (FDC-Pmix) depend on IL-3 for self-renewal and proliferation and can be induced to differentiate into multiple hematopoietic lineages. Single FDC-Pmix cells infected with retroviral vectors expressing GM-CSF are induced to differentiate into granulocytes and mac...
Topics
- Animals
- Cell Differentiation
- Cell Division
- Cell Line
- Genetic Vectors
- Granulocyte-Macrophage Colony-Stimulating Factor
- Granulocytes
- Hematopoietic Stem Cells
- Interleukin-3
- Macrophages
- Mice
- Mutation
- Retroviridae