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Article

Signal-response coupling mediated by the transduced colony-stimulating factor-1 receptor and its oncogenic fms variants in naive cells.

Ciba Foundation symposium - 1 Jan 1990

Sherr C J, Kato J Y, Borzillo G, Downing J R, Roussel M F

Abstract excerpt

Colony-stimulating factor-1 (CSF-1 or M-CSF) supports the proliferation and survival of mononuclear phagocytes by binding to a receptor (CSF-1R) encoded by the c-fms proto-oncogene. Whereas the CSF-1R kinase is normally regulated by ligand, receptors bearing 'activating mutations' act constitutively as enzymes and can transform fibroblasts and haemopoietic cells of different lineages. Introduction of human CSF-1R...

Topics

Animals
Cell Line, Transformed
Cell Transformation, Neoplastic
Humans
Mice
Mutation
Proto-Oncogene Mas
Proto-Oncogene Proteins
Receptor, Macrophage Colony-Stimulating Factor
Receptors, Cell Surface

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Receptors, Colony-Stimulating Factor

Signal Transduction

Source

Identifiers

PMID: 2156660
DOI: 10.1002/9780470513880.ch7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2156660-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Signal-response coupling mediated by the transduced colony-stimulating factor-1 receptor and its oncogenic fms variants in naive cells.PMID 2156660Read ↗

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