Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Dual reporter system to dissect cis- and trans-effects influencing the mutation rate in a hypermutating cell line.

Molecular immunology - 1 Nov 2004

Ruckerl Florian, Mailhammer Reinhard, Bachl Jurgen

Abstract excerpt

Activation induced cytidine deaminase (AID) plays a key role in the induction of somatic hypermutation and class switching in the immunoglobulin genes of B-lymphocytes. AID expression by itself is sufficient to induce a GC-basepair biased mutator phenotype in lymphoid and non-lymphoid cell lines. Nevertheless a network of cis-regulatory elements and additional trans-factor proteins seems to govern the molecular...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to AICDA (Activation-Induced Cytidine Deaminase)
Share to B-Lymphocytes

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Cytidine Deaminase

Share to Down-Regulation

Share to Genes, Reporter

Share to Green Fluorescent Proteins

Share to Kinetics

Share to Somatic Hypermutation, Immunoglobulin

Source

Identifiers

PMID: 15482849
DOI: 10.1016/j.molimm.2004.06.030

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Dual reporter system to dissect cis- and trans-effects influencing the mutation rate in a hypermutating cell line.PMID 15482849Read ↗

Activation-induced cytidine deaminase fails to induce a mutator phenotype in the human pre-B cell line Nalm-6.Semantic proximity Read ↗

AID-GFP chimeric protein increases hypermutation of Ig genes with no evidence of nuclear localizationSemantic proximity Read ↗

Somatic hypermutation of the AID transgene in B and non-B cellsSemantic proximity Read ↗

A cis-acting diversification activator both necessary and sufficient for AID-mediated hypermutation.Semantic proximity Read ↗

High levels of AID cause strand bias of mutations at A versus T in Burkitt's lymphoma cells.Semantic proximity Read ↗

Mutational activity in cell line WEHI-231.Semantic proximity Read ↗

Rapid cell division contributes to efficient induction of A/T mutations during Ig gene hypermutation.Semantic proximity Read ↗

AID enzyme-induced hypermutation in an actively transcribed gene in fibroblasts.Semantic proximity Read ↗

Recombinogenic phenotype of human activation-induced cytosine deaminase.Semantic proximity Read ↗

A target selection of somatic hypermutations is regulated similarly between T and B cells upon activation-induced cytidine deaminase expression.Semantic proximity Read ↗

A Rapid and Precise Mutation-Activated Fluorescence Reporter for Analyzing Acute Mutagenesis Frequency.Semantic proximity Read ↗

Activation induced cytidine deaminase mutant (AID-His130Pro) from Hyper IgM 2 patient retained mutagenic activity on SHM artificial substrate.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.