Article
Mutants of a multipotent hematopoietic cell line blocked in GM-CSF-induced differentiation are leukemogenic in vivo.
Experimental hematology - 1 Aug 1994
Just U, Spooncer E, Löhler J, Stocking C, Ostertag W, Dexter T M
Abstract excerpt
FDCP-Mix cells infected with a retroviral vector expressing the GM-CSF gene (GMV-FDCP-Mix) self-renew in the presence of interleukin-3 (IL-3), are multipotent, and undergo differentiation into granulocytes and macrophages coupled with clonal extinction after removal of IL-3. Mutants of GMV-FDCP-M...
Topics
- Animals
- Cell Differentiation
- Cell Line
- Cell Transformation, Neoplastic
- DNA, Neoplasm
- Gene Expression Regulation
- Granulocyte-Macrophage Colony-Stimulating Factor
- Granulocytes
- Hematopoiesis
- Hematopoietic Stem Cells
- Interleukin-3
- Leukemia, Myelogenous, Chronic, BCR-ABL Positive
- Macrophages
- Mice
- Mutation