Article
Association between CDH1 haplotypes and gastric cancer risk in a Japanese population.
Scandinavian journal of gastroenterology - 1 Dec 2007
Yamada Hidetaka, Shinmura Kazuya, Ikeda Shinobu, Tao Hong, Otani Tetsuya, Hanaoka Tomoyuki, Tsuneyoshi Toshihiro, Tsugane Shoichiro, Sugimura Haruhiko
Abstract excerpt
OBJECTIVE: A c. -285C >A single nucleotide polymorphism (SNP) in the promoter region of the E-cadherin (CDH1) gene, which is a tumor suppressor in gastric cancer (GC), has been shown to decrease gene transcription, but GC case-control studies of this SNP have yielded controversial results. A haplotype study in an Italian population showed that haplotypes based on three SNPs, including the c. -285C >A, are...
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