Article
Presymptomatic identification of CDH1 germline mutation in a healthy korean individual with family history of gastric cancer.
Annals of laboratory medicine - 1 Sept 2014
Choi Hyun-Jung, Ki Chang-Seok, Suh Soon-Pal, Kim Jong-Won
Abstract excerpt
Gastric cancer (GC) is one of the most common cancers with high morbidity and mortality. Familial GC is seen in 10% of cases, and approximately 3% of familial GC cases arise owing to hereditary diffuse gastric cancer (HDGC). CDH1, which encodes the protein E-cadherin, is the only gene whose mutat...
Topics
- Adult
- Antigens, CD
- Asian People
- Cadherins
- Exons
- Genetic Counseling
- Genetic Predisposition to Disease
- Genetic Testing
- Germ-Line Mutation
- Heterozygote
- Humans
- Male