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Article

Germline CDH1 deletions in hereditary diffuse gastric cancer families

24 Jan 2009

Abstract excerpt

Germline CDH1 point or small frameshift mutations can be identified in 30-50% of hereditary diffuse gastric cancer (HDGC) families. We hypothesized that CDH1 genomic rearrangements would be found in HDGC and identified 160 families with either two gastric cancers in first-degree relatives and with at least one diffuse gastric cancer (DGC) diagnosed before age 50, or three or more DGC in close relatives diagnosed...

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PMID: 19168852
DOI: 10.1093/hmg/ddp046

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