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Article

The TRIM5 gene modulates penile mucosal acquisition of simian immunodeficiency virus in rhesus monkeys.

Journal of virology - 1 Oct 2011

Yeh Wendy W, Rao Srinivas S, Lim So-Yon, Zhang Jinrong, Hraber Peter T, Brassard Laura M, Luedemann Corinne, Todd John Paul, Dodson Alan, Shen Ling, Buzby Adam P, Whitney James B, Korber Bette T, Nabel Gary J, Mascola John R, Letvin Norman L

Abstract excerpt

There is considerable variability in host susceptibility to human immunodeficiency virus type 1 (HIV-1) infection, but the host genetic determinants of that variability are not well understood. In addition to serving as a block for cross-species retroviral infection, TRIM5 was recently shown to play a central role in limiting primate immunodeficiency virus replication. We hypothesized that TRIM5 may also...

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Source

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Identifiers

PMID: 21775457
DOI: 10.1128/JVI.00854-11
PMCID: PMC3196432

Genes

TRIM5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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