Article
Effects of human TRIM5alpha polymorphisms on antiretroviral function and susceptibility to human immunodeficiency virus infection.
Virology - 10 Oct 2006
Javanbakht Hassan, An Ping, Gold Bert, Petersen Desiree C, O'Huigin Colm, Nelson George W, O'Brien Stephen J, Kirk Gregory D, Detels Roger, Buchbinder Susan, Donfield Sharyne, Shulenin Sergey, Song Byeongwoon, Perron Michel J, Stremlau Matthew, Sodroski Joseph, Dean Michael, Winkler Cheryl
Abstract excerpt
TRIM5alpha acts on several retroviruses, including human immunodeficiency virus (HIV-1), to restrict cross-species transmission. Using natural history cohorts and tissue culture systems, we examined the effect of polymorphism in human TRIM5alpha on HIV-1 infection. In African Americans, the frequencies of two non-coding SNP variant alleles in exon 1 and intron 1 of TRIM5 were elevated in HIV-1-infected persons...
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