The TRIM5{alpha} genotype of rhesus macaques affects acquisition of simian immunodeficiency virus SIVsmE660 infection after repeated limiting-dose intrarectal challenge.

doi:10.1128/JVI.05074-11

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

The TRIM5{alpha} genotype of rhesus macaques affects acquisition of simian immunodeficiency virus SIVsmE660 infection after repeated limiting-dose intrarectal challenge.

Journal of virology - 1 Sept 2011

Reynolds Matthew R, Sacha Jonah B, Weiler Andrea M, Borchardt Gretta J, Glidden Chrystal E, Sheppard Neil C, Norante Francesca A, Castrovinci Philip A, Harris Jacqueline J, Robertson Henry T, Friedrich Thomas C, McDermott Adrian B, Wilson Nancy A, Allison David B, Koff Wayne C, Johnson Welkin E, Watkins David I

Abstract excerpt

It has recently been shown that polymorphism at the rhesus macaque TRIM5 locus can affect simian immunodeficiency virus (SIV) replication. Here we show that TRIM5 alleles can also affect acquisition of SIVsmE660. Animals coexpressing the TRIM5(TFP) and TRIM5(CypA) alleles took significantly longer to become infected with SIVsmE660, but not SIVmac239, after repeated limiting-dose intrarectal challenge than did...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Immunity, Innate

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Macaca mulatta

Share to Polymorphism, Genetic

Share to Proteins

Share to Rectum

Share to Simian Acquired Immunodeficiency Syndrome

Share to Simian Immunodeficiency Virus

Share to Ubiquitin-Protein Ligases

Source

Open in PubMed Open full text

Identifiers

PMID: 21734037
DOI: 10.1128/JVI.05074-11
PMCID: PMC3165772

Genes

TRIM5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The TRIM5{alpha} genotype of rhesus macaques affects acquisition of simian immunodeficiency virus SIVsmE660 infection after repeated limiting-dose intrarectal challenge.PMID 21734037Read ↗

TRIM5 alpha drives SIVsmm evolution in rhesus macaques.Semantic proximity Read ↗

The TRIM5 gene modulates penile mucosal acquisition of simian immunodeficiency virus in rhesus monkeys.Semantic proximity Read ↗

Rhesus macaque TRIM5 alleles have divergent antiretroviral specificities.Semantic proximity Read ↗

TRIM5alpha Modulates Immunodeficiency Virus Control in Rhesus Monkeys.Semantic proximity Read ↗

Upregulation of TRIM5α gene expression after live-attenuated simian immunodeficiency virus vaccination in Mauritian cynomolgus macaques, but TRIM5α genotype has no impact on virus acquisition or vaccination outcome.Semantic proximity Read ↗

TRIM5 allelic polymorphism in macaque species/populations of different geographic origins: its impact on SIV vaccine studies.Semantic proximity Read ↗

TRIM5 suppresses cross-species transmission of a primate immunodeficiency virus and selects for emergence of resistant variants in the new species.Semantic proximity Read ↗

TRIM5α restriction affects clinical outcome and disease progression in simian immunodeficiency virus-infected rhesus macaques.Semantic proximity Read ↗

Susceptibility to repeated, low-dose, rectal SHIVSF162P3 challenge is independent of TRIM5 genotype in rhesus macaques.Semantic proximity Read ↗

Effects of human TRIM5alpha polymorphisms on antiretroviral function and susceptibility to human immunodeficiency virus infection.Semantic proximity Read ↗

Independent evolution of an antiviral TRIMCyp in rhesus macaquesSemantic proximity Read ↗

Evolution of a TRIM5-CypA splice isoform in old world monkeys.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.