Article
A role for Snf2-related nucleosome-spacing enzymes in genome-wide nucleosome organization.
Science (New York, N.Y.) - 23 Sept 2011
Gkikopoulos Triantaffyllos, Schofield Pieta, Singh Vijender, Pinskaya Marina, Mellor Jane, Smolle Michaela, Workman Jerry L, Barton Geoffrey J, Owen-Hughes Tom
Abstract excerpt
The positioning of nucleosomes within the coding regions of eukaryotic genes is aligned with respect to transcriptional start sites. This organization is likely to influence many genetic processes, requiring access to the underlying DNA. Here, we show that the combined action of Isw1 and Chd1 nucleosome-spacing enzymes is required to maintain this organization. In the absence of these enzymes, regular positioning...
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