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Article

TWIST1 expression is associated with high-risk neuroblastoma and promotes primary and metastatic tumor growth

12 Jan 2022

Abstract excerpt

The embryonic transcription factors TWIST1/2 are frequently overexpressed in cancer, acting as multifunctional oncogenes. Here we investigate their role in neuroblastoma (NB), a heterogeneous childhood malignancy ranging from spontaneous regression to dismal outcomes despite multimodal therapy. We first reveal the association of TWIST1 expression with poor survival and metastasis in primary NB, while TWIST2...

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PMID: 35022561
DOI: 10.1038/s42003-021-02958-6

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